What is the best duration for nicotine replacement therapy?


  • —525 smokers enrolled.
  • —Randomized groups for nicotine replacement via patch at 8, 24, 52 weeks
  • —6 month cessation rates were significantly higher if patches used for 24 wks. vs 8 wks.
  • —No adverse effects noted
  • —Cost effective benefit long term.
  • —No additional therapeutic advantage with long term treatment (up to 52 weeks)
  • —Worsened adherence after 24 weeks
  • —Likely difficulties adhering to patch treatment for such a long period of time.


  • 24 week duration of treatment is best.
  • —Suggested use of Champix (varencicline tartrate) or combination nicotine replacement therapy for better results.

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